Who should do PGT-M?

PGT-M is for couples with a known, specific inherited condition in the family, where the gene change has been identified. Typical situations: Both partners carry the same recessive condition — thalassaemia, cystic fibrosis, sickle cell disease, spinal muscular atrophy. One partner has a dominant condition that can be passed on. A woman carries an X-linked condition such as haemophilia or Duchenne muscular dystrophy. A previous child is affected by an inherited condition. One partner carries a known cancer predisposition — though for adult-onset conditions this involves additional considerations, discussed separately. The prerequisite is that the specific gene change must be identified first. PGT-M cannot be designed around a condition in the family that has never been genetically confirmed. If a relative is affected but no genetic testing has been done, that testing needs to happen before PGT-M is possible — which takes time and requires that relative's cooperation. Who it is not for: couples without a known condition who want general reassurance. That is not what PGT-M does. Before committing, ask a genetic counsellor to lay out all your options, not only PGT-M. For many conditions, natural conception with prenatal diagnosis is a reasonable alternative, avoids IVF entirely, and is significantly less expensive. Donor gametes are another route. Which is right depends on the condition, your feelings about the alternatives, and your circumstances. If you are already having IVF for fertility reasons, adding PGT-M is a smaller step than starting IVF solely for it.