Should I repeat NIPT after inconclusive results?

Usually yes as a first step, and most women get a valid result on the second attempt. A repeat sample slightly later in pregnancy allows the proportion of placental DNA to rise, which addresses the commonest cause of an inconclusive result. If the second sample also fails, repeating a third time is generally not the best use of time. ACMG's position is that counselling after an uninformative result should include the offer of diagnostic testing — CVS or amniocentesis — which does not depend on fetal fraction and gives a definitive answer. Your options at that point: Repeat NIPT once more, accepting it may fail again. Move to diagnostic testing. Decline further testing and continue with routine antenatal care including your anomaly scan. All three are reasonable, and the right choice depends on how much the information matters to you and how you feel about a procedure. Two practical points: ask whether a repeat is charged, and be aware that each repeat consumes time. If you are approaching the gestational limit for diagnostic testing or for the decisions you might make afterwards, repeated attempts at NIPT can leave you with fewer options. Ask your obstetrician what the timeline looks like from here, so the decision is made with the calendar in view rather than in retrospect.